Sildenafil Oral Film: Package Insert / Prescribing Info
Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers. Pharmacokinetic comparison of an orally disintegrating film formulation with a film-coated tablet formulation of sildenafil in healthy Korean subjects: a randomized, open-label, single-dose, 2-period crossover study. Bioequivalence and bioavailability of an Orodispersible tablet of sildenafil citrate in healthy Chinese male subjects. Bioequivalence studies of sildenafil citrate orodispersible film administered with sildenafil 50 mg tab and without water versus Viagra® film-coated tablets in healthy male subjects. EDEUS, a real-life study on the users of phosphodiesterase type 5 inhibitors: prevalence, perceptions, and health care-seeking behavior among European men with a focus on 2nd-generation avanafil.
- Sildenafil film tablets are oral medications used to treat erectile dysfunction.
- These tablets are smooth, coated, and designed for quick swallowing.
- They contain sildenafil citrate as the active ingredient.
Health-related characteristics and unmet needs of men with erectile dysfunction: a survey in five European countries. Andersson K-E. Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction.
UK Registered Pharmacy
Drug-delivery products and the zydis fast-dissolving dosage form. A review on mouth dissolving tablet techniques. Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies. Puttalingaiah L, Kavitha K, Mani T. Fast disintegrating tablets: an overview of formulation, technology and evaluation.
Sildenafil side effects
Formulation evaluation of mouth dissolving tablets of fenofibrate using sublimation technique. Present investigations and future prospects of oral disintegrating tablets: a review. Mouth dissolving tablets: an overview on future compaction in oral formulation technologies. Nayak AK, Manna K. Current developments in orally disintegrating tablet technology.
Pulmonary Arterial Hypertension
Chauhan K, Solanki R, Sharma S. A review on fast dissolving tablet. Orodispersible films: current innovations and emerging trends. Gijare C, Deshpande A. Orodispersible films: a systematic patent review. Anatomy, physiology, and pathophysiology of erectile dysfunction. The Italian society of Andrology and sexual medicine (SIAMS), along with ten other Italian scientific societies, guidelines on the diagnosis and management of erectile dysfunction. Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction: pharmacology and clinical impact of the sildenafil citrate orodispersible tablet formulation. Subclinical erectile dysfunction: proposal for a novel taxonomic category in sexual medicine. Prevalence of erectile dysfunction in a cohort of Italian hypertensive subjects. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. Erectile dysfunction and cardiovascular risk: a review of current findings. SM= SM: the interface of systems medicine and sexual medicine for facing non-communicable diseases in a gender-dependent manner. Insights into modifiable risk factors of erectile dysfunction, a wide-angled mendelian randomization study.
| Population Group | Frequency |
|---|---|
| Adults with ED | Once per day as needed |
| Patients with PAH | As prescribed by physician |
| Special considerations | Avoid exceeding prescribed dosage |
Prediction of cardiovascular events and all-cause mortality with erectile dysfunction: a systematic review and meta-analysis of cohort studies. Comment on “association between cardiometabolic index and erectile dysfunction among US adults: a cross-sectional analysis of the national health and nutrition examination survey 2001–2004”.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Soft Tabs | 100mg | 120 + 6 Pills | 311.78€ 296.93€ | |
| Viagra Generic | 50mg | 120 + 6 Pills | 129.64€ 123.47€ | |
| Viagra Generic | 200mg | 360 + 10 Pills | 481.98€ 459.03€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ | |
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Viagra Generic | 25mg | 270 + 8 Pills | 184.26€ 175.49€ | |
| Viagra Generic | 100mg | 360 + 10 Pills | 330.21€ 314.49€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ |
Type 5 phosphodiesterase (PDE5) and the vascular tree: from embryogenesis to aging and disease.
SILDESAPH Sildenafil Citrate 50mg Film Coated Tablet 4's
Recent trends of fast dissolving tablet-an overview of formulation technology. Recent trends of fast dissolving drug delivery system-an overview of formulation technology. Comoglu T, Dilek Ozyilmaz E. Orally disintegrating tablets and orally disintegrating mini tablets–novel dosage forms for pediatric use. Arora P, Sethi VA.
Sildenafil Oral Film for ED
Orodispersible tablets: a comprehensive review. A novel approach for drug delivery system in orodispersible tablet. A comprehensive review of patented technologies to fabricate orodispersible films: proof of patent analysis (2000–2020). Shanmugam S. Granulation techniques and technologies: recent progresses.
4.1 Nitrates
Kumar AK, Nayyar P, Kumar S. Fast dissolving tablets-A review. Aarti J, Sonali J, Ganesh D. Orodispersible tablets: a comprehensive review. Seager H. Evaluation and management of erectile dysfunction in clinical practice. Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles. Evans JD, Hill SR. A comparison of the available phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction: a focus on avanafil. The ENDOTRIAL study: a spontaneous, open-label, randomized, multicenter, crossover study on the efficacy of sildenafil, tadalafil, and vardenafil in the treatment of erectile dysfunction. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Viagra 50 mg film-coated tablets - summary of product characteristics (SmPC) - (emc). [ updated 2023 May 4; cited 2024 Mar 6]. The first‐generation phosphodiesterase 5 inhibitors and their pharmacokinetic issue. Pharmacokinetics of a novel orodispersible tablet of sildenafil in healthy subjects.
- Sildenafil film tablets are available by prescription only.
- They may interact with nitrates, causing dangerous blood pressure drops.
- Alcohol can impair the effectiveness of these tablets.
Clinical analysis on the pharmaceutical formulation of VIAGRA OD film. First‐generation phosphodiesterase type 5 inhibitors dropout: a comprehensive review and meta‐analysis.
| Contraindication | Explanation |
|---|---|
| Use with Nitrates | Risk of severe hypotension |
| History of Priapism | May cause prolonged erections |
| Severe Cardiovascular Disease | Increased risk of adverse events |
| Eye Disorders (e.g., Non-arteritic ischemic optic neuropathy) | Caution advised |
Bioerodable film for delivery of pharmaceutical compounds of mucosal surfaces. United States patent US 6,159,498. Preparation of a fast dissolving oral thin film containing dexamethasone: a possible application to antiemesis during cancer chemotherapy. Patel P, Prajapati BG, Patel D.
3. Dosage Forms and Strengths
Orodispersible films—pharmaceutical development for improved performance: a review. Orodispersible film, a new concept in drug delivery technology. Preparation, characterization and in vitro evaluation of a polyvinyl alcohol/sodium alginate based orodispersible film containing sildenafil citrate. Designing orodispersible films containing everolimus for enhanced compliance and bioavailability. Patel P, Prajapati sildenafil 100 mg cost B, Patel D.
8.5 Geriatric Use
Innovative approaches in designing a pregabalin orodispersible film for epilepsy treatment. Orodispersible films containing ball milled aripiprazole-poloxamer(R)407 solid dispersions. Thakkar S, Misra M. Electrospun polymeric nanofibers: new horizons in drug delivery. Incorporation of lysozyme into a mucoadhesive electrospun patch for rapid protein delivery to the oral mucosa.
Pregnancy Categories
Electrospinning of pullulan-based orodispersible films containing sildenafil. Recent progress in orodispersible films‐mediated therapeutic applications: a review. Continuous inkjet printing of enalapril maleate onto orodispersible film formulations. Polymers for extrusion-based 3D printing of pharmaceuticals: a holistic materials–process perspective. Drug-printing by flexographic printing technology—a new manufacturing process for orodispersible films. Mouth dissolving film as a potential dosage form for paediatric usage. Wasilewska K, Winnicka K. How to assess orodispersible sildenafil softgel capsule film quality? A review of applied methods and their modifications. Sildenafil is commonly used for the following conditions. Erectile dysfunction, a condition where you have trouble getting or keeping an erection Pulmonary arterial hypertension, a condition where you have high blood pressure in the blood vessels that carry blood from your heart to your lungs Sildenafil may also be used for other conditions as determined by your healthcare provider. Sildenafil works by blocking an enzyme in the body called PDE5, which helps relax certain blood vessels.
What other information should I know?
3D printing technologies: recent development and emerging applications in various drug delivery systems. Woertz C, Kleinebudde P. Development of orodispersible polymer films with focus on the solid state characterization of crystalline loperamide. Characterization of hydrophilic polymers as a syringe extrusion 3D printing material for orodispersible film. Semi-solid extrusion 3D printing ODFs: an individual drug delivery system for small scale pharmacy. For erectile dysfunction, it increases blood flow to the penis when aroused.
6.1 Clinical Trials Experience
Preis M, Breitkreutz J, Sandler N. Perspective: concepts of printing technologies for oral film formulations. The application of 3D printing in the formulation of multilayered fast dissolving oral films. Fused deposition modeling (FDM), the new asset for the production of tailored medicines. 3D printing: innovative solutions for patients and pharmaceutical industry. This makes it easier to get and keep an erection. For pulmonary arterial hypertension, sildenafil relaxes the blood vessels in the lungs. This lowers blood pressure and reduces strain on the heart. 10 mg/mL powder for oral suspension 20 mg, 25 mg, 50 mg, 100 mg oral tablets Sildenafil is also available in an injectable form that is usually given by a healthcare provider in a hospital or clinic. Sildenafil oral tablets should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Sildenafil oral liquid should be stored at room temperature below 86 F (30 C) or in the refrigerator, between 36 F to 46 F (2 C to 8 C). Throw away any remaining liquid 60 days after it has been mixed for you by a pharmacist or healthcare professional. Sildenafil injection is usually given by a healthcare provider in a hospital or clinic. You will not store it at home.
- These tablets provide a discreet alternative to traditional pills.
- They are designed to dissolve quickly in the mouth or be swallowed.
- Suitable for people who have difficulty swallowing capsules.
The most common side effects of sildenafil are listed below. These side effects may vary depending on the condition that is being treated. Tell your healthcare provider if you have any of these side effects that bother you. Pain in your muscles, back, arms, or legs There may be other side effects of sildenafil that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at or by calling 866-234-2345.