RECENT MAJOR CHANGES

Sildenafil can cause a serious drop in your blood pressure when used with nitrates.

• Store sildenafil tablets in a cool, dry place away from moisture.
• Keep out of reach of children and pets.
• Expiry date can be checked on the packaging.

A serious drop in blood pressure can lead to dizziness, fainting, and rarely heart attack or stroke. Do not use sildenafil with any of the following: certain drugs used to treat chest pain/angina (nitrates such as nitroglycerin, isosorbide), recreational drugs called "poppers" containing amyl or butyl nitrite. If you are also taking an alpha blocker medication (such as doxazosin, tamsulosin) to treat an enlarged prostate/BPH or high blood pressure, your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may start treatment with a lower dose of sildenafil to minimize your risk of low blood pressure.

Detection in biological fluids

Premature ejaculation (PE) is a sexual dysfunction characterized by a short ejaculatory latency, a perceived lack of control about the timing of ejaculation, and distress and interpersonal difficulty related to ejaculating too quickly. Low testosterone or testosterone deficiency, also known as hypogonadism, is a condition in which patients develop symptoms such as low sex drive, erectile dysfunction (ED), and fatigue because the body doesn’t produce enough testosterone. Though many men don’t like to talk about it, ejaculation problems are very common. Some of the most common issues include premature, delayed, or retrograde ejaculation. Your pelvic floor is a lot like plumbing in your home: you never really think about it unless something goes wrong.

Drug Interactions

When you think of male sexual dysfunction, concerns like erectile dysfunction (ED) or premature ejaculation (PE) probably come to mind first. But there’s another sex-related issue that’s more common in men than you might expect: difficulty orgasming. This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician. Same symptoms don't mean you have the same problem. Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician.

Sildenafil side effects

Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries. If your selected quantity is intended to last longer than one month, please recheck the price using the 3-months supply option. In some cases, the estimated drug price may vary depending on the supply duration. Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works.

Brand / Manufacturer	Average Price (per 30 tablets)	Strengths Available	Brand Type
Viagra (Pfizer)	$60 - $80	25 mg, 50 mg, 100 mg	Brand name
Generic Versions	$10 - $30	25 mg, 50 mg, 100 mg	Generic
Super Cheapest Brands	$5 - $15	50 mg	Over-the-counter or online options

Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), mifepristone, rifampin, ritonavir, among others. Do not take this medication with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil). Store at room temperature away from light and moisture. Keep all medications away from children and pets.

Product	Dosage	Quantity + Bonus	Price
Kamagra Soft Tabs	100mg	272 + 12 Pills	593.42€ 565.16€	Buy
Viagra Generic	25mg	360 + 10 Pills	213.68€ 203.50€	Buy
Kamagra Soft Tabs	100mg	84 + 4 Pills	233.05€ 221.95€	Buy
Kamagra Oral Jelly	100mg	30 + 5 Sachets	136.20€ 129.71€	Buy
Viagra Generic	150mg	90 + 6 Pills	147.18€ 140.17€	Buy
Viagra Generic	200mg	120 + 8 Pills	204.80€ 195.05€	Buy
Viagra Generic	25mg	120 + 6 Pills	125.56€ 119.58€	Buy
Kamagra	100mg	120 + 6 Pills	330.74€ 314.99€	Buy
Kamagra Soft Tabs	100mg	180 + 8 Pills	425.45€ 405.19€	Buy
Kamagra	100mg	20 Pills	86.09€ 81.99€	Buy
Viagra Generic	150mg	30 + 2 Pills	72.32€ 68.88€	Buy
Viagra Generic	50mg	360 + 10 Pills	225.33€ 214.60€	Buy
Viagra Generic	200mg	60 + 4 Pills	125.19€ 119.23€	Buy
Kamagra Soft Tabs	100mg	120 + 6 Pills	311.78€ 296.93€	Buy
Viagra Generic	50mg	60 + 4 Pills	83.93€ 79.93€	Buy

Do not flush medications down the toilet or pour them into a drain unless instructed to do so.

Mechanism of action

This medication may take longer to start working if you take it with a high-fat meal. Do not take more than once daily as needed. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Tell your doctor if your condition does not get better.

Does Viagra work to treat ED?

May cause dizziness This drug may impair the ability to operate a vehicle, vessel (e.g., boat), or machinery. Use care until you become familiar with its effects. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is blue sildenafil listed in this section only if it has been so prescribed by your health care professional. Sildenafil is also available in other brands and strengths for high blood pressure in the lungs (pulmonary hypertension). Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Ask a clinical question and tap into Healio AI's knowledge base.

• Sildenafil is not an aphrodisiac and needs sexual stimulation.
• It does not increase libido directly.
• Effectiveness varies between individuals.

Healio's exclusive daily news coverage of clinical data Selected from data included with permission and copyrighted by FDB, Inc.

• Sildenafil is generally safe when used as prescribed.
• Always follow your healthcare provider’s dosage instructions.
• Do not double doses if a dose is missed.

This copyrighted material has been downloaded from a licensed data provider and is not for distribution in professional health care settings. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional.

• Sildenafil interacts with nitrates, causing dangerous blood pressure drops.
• Consult a doctor before starting if on other medications.
• Alcohol may reduce the effectiveness and increase side effects.

The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you. You should consult your healthcare professional before taking any drug, changing your diet or commencing or discontinuing any course of treatment.

5.4 Visual Loss

You may find alternative ways to save with this medication. Talk to your pharmacist about the potential option(s) noted below. View images of SILDENAFIL CITRATE (Generic for REVATIO) and identify pills by imprint, color or shape. If you need to save money on your SILDENAFIL CITRATE (Generic for REVATIO), compare our prices. Our prescription savings may even be lower than your insurance copay!

Missed Dose Instructions

Note: Multiple images may be displayed for medicines available in different strengths, sold under different brand names, or manufactured by different pharmaceutical companies. Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a person get and keep an erection. This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). To decrease your risk of infection, always use an effective barrier method (latex or polyurethane condom/dental dams) during all sexual activity.

Antiretroviral Agents

Consult your doctor or pharmacist for more details. 25 mg Brand(s): (of Sildenafil Tablets film-coated sildenafil)* Viagra(R), Pfizer 50 mg Brand(s): (of Sildenafil Tablets Pfizer sildenafil)* Viagra(R), Pfizer 100 mg Brand(s): (of Sildenafil Tablets Pfizer sildenafil)* Viagra(R), Pfizer Read the Patient Information Leaflet if available from your pharmacist before you start taking sildenafil and each time you get a refill. If you have any questions, ask your doctor or pharmacist. To treat erectile dysfunction-ED, take this drug by mouth as directed by your doctor, usually as needed. Take sildenafil at least 30 minutes, but no more than 4 hours, before sexual activity (1 hour before works best). This information is generalized and not intended as specific medical advice.

Indication	Description	Approved Dose	Additional Notes
Erectile Dysfunction (ED)	Improves erectile response in men	50 mg as needed	Taken 30 min to 1 hour before activity
Pulmonary Arterial Hypertension	Vasodilation of pulmonary vasculature	20 mg TID	Used with other PAH therapies
Raynaud's Phenomenon	Relief from vasospasms	Off-label	Experimental use

Consult your healthcare professional before taking any drug or commencing or discontinuing any course of treatment.

Advice To Patients

chronic kidney disease stage 4 (severe) GFR 15-29 mL/min chronic kidney disease stage 5 (failure) GFR<15 mL/min kidney disease with likely reduction in glomerular filtration rate (GFR) Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug are: riociguat, vericiguat. [1][2][4][5][7][8][10][24][27][33][41][56][57][67][91][131] Brand Name: Vybrique, ViagraClasses: Phosphodiesterase Type 5 Inhibitors (24:08.12), Phosphodiesterase type 5 inhibitors (48:48.24) Sildenafil citrate (Viagra® and generic equivalents) is used orally for the treatment of erectile dysfunction (ED, impotence). [1][4][6][7][8][9][10][25][33][34][67][81][102][104][105][107][108][112][118][126][127][128][129][130][131][132][133][134][140][142][143][144][189] A thorough medical, sexual and psychosocial history, physical examination, and selective laboratory testing should be undertaken to diagnose ED, determine potential underlying causes, exclude potentially reversible or treatable causes (e.g., hypogonadism with inadequate testosterone replacement, hyperprolactinemia, drug-induced dysfunction, dyslipidemias, alcoholism, other substance abuse, hypertension, thyroid disease, cardiovascular or cerebrovascular disease, neurologic disease, adrenal dysfunction, psychologic dysfunction, marital discord, smoking), and identify appropriate treatment in conjunction with or prior to initiating vasoactive therapy (e.g., PDE 5 type inhibitor). [12][28][30][31][57][65][66][70][78][83][94][144][145][160][161][189][601][602][603] A review of the patient's current drug regimens should be conducted to detect possible drug-induced ED (e.g., certain antihypertensive, antidepressant, antipsychotic, or antiarrhythmic agents); it may be possible to substitute alternative drug(s) that lessen the risk of such dysfunction.

Study	Population Sample	Improvement Rate	Onset Time	Notes
Phase III Trial A	500 men with ED	85% reported improvement	30-60 min	Compared with placebo
Phase III Trial B	300 women (off-label use)	Variable, limited evidence	N/A	Under investigation for other indications
Post-marketing Data	10,000+ patients	80-90% efficacy reported	Varies	Real-world effectiveness observations

[12][28][70][81][118][144][161][602][603] In instances where substitution therapy is not feasible, concomitant vasoactive therapy with a PDE 5 type inhibitor may promote patient compliance by counteracting ED as an adverse effect. [12][28][70][81][118][144][161][602][603] Efficacy of sildenafil is variable in patients with ED, in part depending on the underlying etiology, severity, and dose employed, but the drug generally appears to be effective in restoring sexual function to an acceptable level in the majority of treated men.